Juvena Therapeutics, Author at Juvena Therapeutics

JOSEPH MILETICH, MD, PHD

Joseph Miletich, MD, PhD, is a former SVP, Research Sciences, at Merck. He has more than 20 years of combined experience at Merck and Amgen leading programs through Discovery Research, Preclinical Development and Translational Medicine/Early Development. At both companies, Dr. Miletich focused on building teams and investing in technologies, partnerships and acquisitions to enable capitalizing on new insights into biology regardless of therapeutic area or modality. Dr. Miletech currently serves as advisor and board director to several companies and firms. Most recently, Dr. Miletich was Merck Research Laboratories’ senior vice president of research sciences and is currently senior scientific advisor to Merck’s CEO, an advisor to Recursion, and a director to Flame Biosciences, among other roles. . Prior to his last 8+ years at Merck Research Laboratories, Dr. Miletich served as senior vice president of research and development at Amgen.

Dr. Miletich received his M.D. and Ph.D. degrees from Washington University in St. Louis and pursued clinical training in internal medicine at the University of California in San Francisco. Subsequently he joined the faculty at Washington University, pursued subspecialty training in clinical hematology and in laboratory medicine, and developed a leading research effort in hemostasis and thrombosis. Over a 17 year career, he rose through the ranks to become Professor of Medicine and Pathology and Head of the Division of Laboratory Medicine at Washington University, in which capacity he was responsible for the combined laboratories of the Barnes-Jewish Hospital system, one of the nation’s largest clinical laboratories.

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John W. Day, MD, PhD

Since 2011 John has been Professor of Neurology, Pediatrics (Genetics) and Pathology at Stanford University, where he is Director of the Division of Neuromuscular Medicine. He received his MD from the University of Minnesota, and PhD in Neuroscience from Albert Einstein College of Medicine, where he studied neuronal electrophysiology, synaptic physiology and plasticity. After completing neurology and neuromuscular training at UCSF, he was Professor of Neurology, Pediatrics and Genetics at the University of Minnesota, where he founded and directed the Paul and Sheila Wellstone Muscular Dystrophy Center.

John has investigated the genetic causes and multisystemic effects of neuromuscular disorders and has more than 35 years of experience designing and directing clinical trials of novel therapeutics. He spearheaded clinical research on spinal muscular atrophy (SMA) at Stanford, which resulted in the approval of antisense and AAV-gene replacement treatments, and led to nationwide newborn screening for SMA and institution of neonatal genetic treatment.

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Tina Duong PT, PHD

Tina Duong is the Director of clinical outcomes research and development at Stanford University Neuromuscular division. Clinically, she is a physical therapist with 20 years of clinical experience in evaluating, treating and validating clinical outcomes for patients with neuromuscular disease.

Her clinical and research interests are in developing, refining and understanding impacts of muscle imbalances and pathology on function and performance. Her work has contributed to improved understanding and characterization of disease phenotypes impacting clinical trial design and care management.

Currently, her research focuses on the effect of exercise and physical activity on human movement and disease physiology. She hopes to integrate technology and digital biomarkers as a complementary tool to performance based measures used in trials, in the clinic and remotely. She enjoys working on collaborative diverse inter-disciplinary teams, mentorship and creating patient focused solutions to improve the quality of life for individuals with neuromuscular disease.

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Christopher Kirk, PhD

Christopher Kirk, PhD is an independent director, scientific and strategic advisor to Juvena Therapeutics. He is the co-founder, President and Chief Scientific Officer of Kezar Life Sciences, a publicly traded company developing first-in-class, small molecule therapies designed to inhibit multiple disease-driving cellular pathways by targeting key intracellular proteins. Dr. Kirk is an immunologist and tumor biologist by training. Prior to founding Kezar, he was the Vice President of Research at Onyx Pharmaceuticals where he played a key leadership role in the discovery and development of 2 proteasome inhibitors, including carfilzomib (KYPROLIS™), currently approved for the treatment of multiple myeloma. Dr. Kirk has authored multiple publications in several select journals including Cell, Nature Medicine, and Nature Reviews and is listed as an inventor on over 40 patents. He sits on the scientific advisory board at C4 Therapeutics, Avidity Biosciences, Rain Therapeutics, the Institute of Applied Clinical Science at the M.D. Anderson Cancer Center as well as the leadership council of the Life Sciences Institute of the University of Michigan.

Dr. Kirk received his B.S. in Biochemistry from the University of California, Davis, and his Ph.D. in Cellular and Molecular Biology from the University of Michigan.

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Sarah Tang

Sarah joined Juvena Therapeutics as a Senior Research Associate to contribute to Dr. Fengling Liu’s research on protein expression and purification. She obtained her bachelor’s degree in molecular and cell biology from the University of California, Berkeley.

Before joining Juvena Therapeutics, Sarah worked as a Research Associate in the antibody discovery field, where she attained hybridoma sequences, antibody transient expression, and hit identification. Prior to transitioning to research, Sarah worked in the clinical diagnostics field as a Lab Administrative Manager. She managed lab operations while staying active on the bench.

In Sarah’s free time, she enjoys creating content for her cat’s social media, gaming with friends, and attending ballet performances.

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Annie Yang, MS

Annie joined Juvena Therapeutics as a research associate II working on preclinical in vivo and in vitro disease modeling and drug discovery.

She received her master’s degree in Biomedical Engineering from the University of Southern California. During her time as a graduate student, Annie participated as a research volunteer in an immunology group. Her project focused on investigating the influence of the coronavirus envelope protein on CD1d expression. This experience provided her with valuable training in fundamental molecular techniques, such as genotyping, flow cytometry, western blotting, and conducting in vivo experiments.

Before joining Juvena, Annie worked as a Research Associate in the field of toxicology at Sorrento Therapeutics for one year. In this position, she played a crucial role in supporting the toxicity team, particularly in the tissue cross-reactivity assay. Her responsibilities included performing histological procedures such as embedding and sectioning both paraffin and frozen tissues, conducting H&E staining, IHC, IF, and acquiring images.

During her free time, Annie finds joy in activities such as jogging, hiking, and gaming with her friends.

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Louis J. Aronne, MD, FACP, DABOM

Dr. Louis Aronne is a leading authority on obesity and its treatment. He is the Sanford I. Weill Professor of Metabolic Research and the director of the Comprehensive Weight Control Center in the division of Endocrinology, Diabetes & Metabolism at Weill Cornell Medicine in New York City. A graduate of Johns
Hopkins University School of Medicine, Dr. Aronne is a founder and past chairman of the American Board of Obesity Medicine and a past president of The Obesity Society. He is a founder and Executive Chairman of Intellihealth, a cloud-based weight management system for healthcare providers.

He completed his internship and residency at Albert Einstein College of Medicine and Jacobi Medical Center, followed by a Henry J. Kaiser Family Foundation Fellowship in General Internal Medicine at New York-Presbyterian/Weill Cornell Medical Center.

Dr Lingvay is an active member of the American Diabetes Association, where she has served over the years on several committees, including the Organizing Committee for the Annual Scientific Sessions, Focus on Fellows Advisory Board, WIN-ADA Advisory Board, Grant Review Committee, and the Professional Practice Committee. She is on the Editorial Board of several journals, including Diabetes Care. She participated in nearly 100 clinical trials and has a special interest in cardiovascular outcome trials and obesity trials. She authored over 160 publications in major medical journals and authored chapters in several popular diabetes textbooks.

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Ildiko Lingvay, MD, MPH, MSCS

Dr. Ildiko Lingvay is a Tenured Professor of Medicine in the Division of Endocrinology and Professor in the Peter O’Donnell Jr. School of Public Health at UT Southwestern Medical Center. Dr. Lingvay is the Medical Director of the Office of Clinical Trials Management, overseeing the institutional approval of all clinical trials at UT Southwestern. She is Board Certified both in Obesity Medicine as well as Endocrinology, Diabetes and Metabolism.

Dr Lingvay leads a program that focuses on clinical research in the field of obesity and type 2 diabetes. Her research interests span the spectrum from pathophysiology of the disease to treatment algorithms and comparative effectiveness of various therapeutic approaches. Dr Lingvay treats patients at the UT Southwestern clinics and hospitals as well as the Parkland Health & Hospital System.

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CEO Dr. Hanadie Yousef is interviewed by Ira Pastor for his Progress, Potential, and Possibilities show on Juvena’s development of Secretome Derived Therapies

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Rami Hannoush, PhD

Dr. Hannoush is a general partner at Mubadala Capital, the financial investment arm of the Sovereign Wealth Fund Mubadala. He focuses on early-stage biotechnology investments, and also leads the firm’s efforts in life sciences company creation. Prior to his current position, Dr. Hannoush spent fifteen years at Genentech where he was a Senior Group Leader, and he led both early- and late-stage discovery biology programs in Ophthalmology, Immunology and Oncology, with a focus on drug discovery and development, as well as target discovery and validation.

His former Laboratory in translational biology at Genentech focused on new drug modalities and understanding the role of protein – protein interactions in stem cell signaling pathways for cellular reprogramming and tissue regeneration, and his group made important contributions in the fields of Wnt signaling and protein lipidation. He obtained his PhD in Chemistry from McGill University and did his postdoctoral training in chemical biology and cell biology at Harvard.

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JOSEPH MILETICH, MD, PHD

John W. Day, MD, PhD

Tina Duong PT, PHD

Christopher Kirk, PhD

Sarah Tang

Annie Yang, MS

Louis J. Aronne, MD, FACP, DABOM

Ildiko Lingvay, MD, MPH, MSCS

CEO Dr. Hanadie Yousef is interviewed by Ira Pastor for his Progress, Potential, and Possibilities show on Juvena’s development of Secretome Derived Therapies

Rami Hannoush, PhD

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